Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

Frontiers in Public Health

Public Health

Rosalie Cabry¹  Moncef Benkhalifa¹  Hafida Khorsi-Cauet¹  Marwa Lahimer²  Debbie Montjean³  Habib Ben Ali⁴  Maria Abou Diwan⁵  Véronique Bach⁵  Mounir Ajina⁶ 

[1] ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, CHU Sud, Amiens, France;PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, Amiens, France;ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, CHU Sud, Amiens, France;PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, Amiens, France;Exercise Physiology and Physiopathology: from Integrated to Molecular “Biology, Medicine and Health” (Code: LR19ES09), Sousse, Tunisia;Fertilys, Centres de Fertilité, Laval and Brossard, QC, Canada;Laboratory Histology Embryology, Faculty of Medicine Sousse, University of Sousse, Sousse, Tunisia;PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, Amiens, France;Service of Reproductive Medicine, University Hospital Farhat Hached, Sousse, Tunisia;

关键词: endocrine disrupting chemicals;    pesticides;    spermatogenesis;    sperm characteristics;    hormonal disorders;    epigenetics modification;   

DOI  :  10.3389/fpubh.2023.1232646

 received in 2023-05-31, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

The deleterious effects of chemical or non-chemical endocrine disruptors (EDs) on male fertility potential is well documented but still not fully elucidated. For example, the detection of industrial chemicals’ metabolites in seminal plasma and follicular fluid can affect efficiency of the gametogenesis, the maturation and competency of gametes and has guided scientists to hypothesize that endocrine disrupting chemicals (EDCs) may disrupt hormonal homoeostasis by leading to a wide range of hormonal control impairments. The effects of EDCs exposure on reproductive health are highly dependent on factors including the type of EDCs, the duration of exposure, individual susceptibility, and the presence of other co-factors. Research and scientists continue to study these complex interactions. The aim of this review is to summarize the literature to better understand the potential reproductive health risks of EDCs in France.

【 授权许可】

Unknown   
Copyright © 2023 Lahimer, Abou Diwan, Montjean, Cabry, Bach, Ajina, Ben Ali, Benkhalifa and Khorsi-Cauet.