LCTL Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas

Frontiers in Oncology

Qianquan Ma¹  Changwu Wu²  Mei Luo²  Kai Xiao²  Xiangyu Wang²  Qun Xiao²  Haoyu Li²  Yang Li²  Jun Su²  Wenyong Long²  Chi Zhang²  Qing Liu³  Hailin Tang⁴ 

[1] Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China;Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China;;Institute of Skull Base Surgery &Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;

关键词: Klotho;    LCTL;    immune infiltration;    methylation;    FGF signaling;    glioma;   

DOI  :  10.3389/fonc.2019.01083

来源: DOAJ

【 摘 要 】

Immune evasion in glioma strongly correlates with clinical outcomes; however, the molecular mechanisms driving the maintenance of immunosuppression remain largely unknown. Recently studies demonstrate that Klothos are aberrantly expressed in several cancers and are potential therapeutic targets in cancers. However, their roles are still unclear in glioma. Here, we show that LCTL is highly expressed in gliomas and that its expression is regulated by DNA methylation status at the promoter. LCTL expression is also found to be significantly associated with high tumor aggressiveness and poor outcomes for glioma patients. Mechanistically, results suggested that LCTL might play an important immunosuppressive role by recruiting immunosuppressive cells and regulating tumor-associated macrophages polarization, T cell exhaustion, and epithelial–mesenchymal transition through FGF signaling in glioma. Our results establish LCTL as a key biomarker for prognosis that could be considered a potential epigenetic and immunotherapeutic target for treatment.

【 授权许可】

Unknown