期刊论文详细信息
Journal of Hematology & Oncology
Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma
Yiwei Chu1  Feifei Luo1  Kristien Wouters2  Zwi N. Berneman3  Marijke Timmers3  Wilfried Schroyens3  Eva Lion4  Donovan Flumens4  Gils Roex4  Diana Campillo-Davo4  Sébastien Anguille4 
[1] Biotherapy Research Center, Fudan University;Clinical Trial Center, Antwerp University Hospital;Division of Hematology and Center for Cell Therapy & Regenerative Medicine, Antwerp University Hospital;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp;
关键词: BCMA;    CAR-T;    Multiple myeloma;   
DOI  :  10.1186/s13045-020-01001-1
来源: DOAJ
【 摘 要 】

Abstract Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determine its safety and clinical activity and to identify factors influencing these outcomes. Methods We performed a database search using the terms “BCMA,” “CAR,” and “multiple myeloma” for clinical studies published between 01/01/2015 and 01/01/2020. The methodology is further detailed in PROSPERO (CRD42020125332). Results Twenty-three different CAR-T-cell products have been used so far in 640 patients. Cytokine release syndrome was observed in 80.3% (69.0–88.2); 10.5% (6.8–16.0) had neurotoxicity. A higher neurotoxicity rate was reported in studies that included more heavily pretreated patients: 19.1% (13.3–26.7; I 2 = 45%) versus 2.8% (1.3–6.1; I 2 = 0%) (p < 0.0001). The pooled overall response rate was 80.5% (73.5–85.9); complete responses (CR) were observed in 44.8% (35.3–54.6). A pooled CR rate of 71.9% (62.8–79.6; I 2 = 0%) was noted in studies using alpaca/llama-based constructs, whereas it was only 18.0% (6.5–41.1; I 2 = 67%) in studies that used retroviral vectors for CAR transduction. Median progression-free survival (PFS) was 12.2 (11.4–17.4) months, which compared favorably to the expected PFS of 1.9 (1.5–3.7) months (HR 0.14; p < 0.0001). Conclusions Although considerable toxicity was observed, BCMA-targeted CAR-T-cell therapy is highly efficacious even in advanced multiple myeloma. Subgroup analysis confirmed the anticipated inter-study heterogeneity and identified potential factors contributing to safety and efficacy. The results of this meta-analysis may assist the future design of CAR-T-cell studies and lead to optimized BCMA CAR-T-cell products.

【 授权许可】

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