Molecular Mechanisms of Heat Shock Factors in Cancer

Cells

MikaelChrister Puustinen¹  Lea Sistonen¹ 

[1] Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6, 20520 Turku, Finland;

关键词: carcinogenesis;    heat shock factor;    heat shock response;    proteotoxic stress;    transcription;   

DOI  :  10.3390/cells9051202

来源: DOAJ

【 摘 要 】

Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.

【 授权许可】

Unknown