The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

International Journal of Molecular Sciences

Michal Bijak¹  Joanna Saluk-Bijak²  Paulina Wigner² 

[1] Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland;Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland;

关键词: bladder cancer treatment;    curcumin;    sulforaphane;    resveratrol;    quercetin;    6-gingerol;   

DOI  :  10.3390/ijms22157787

来源: DOAJ

【 摘 要 】

Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.

【 授权许可】

Unknown