Phytochemical Modulators of Mitochondria: The Search for Chemopreventive Agents and Supportive Therapeutics

Pharmaceuticals

Maja M. Grabacka¹  Malgorzata Gawin² 

[1] id="af1-pharmaceuticals-07-00913">Department of Food Biotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Krakow, Pola

关键词: resveratrol;    curcumin;    sulforaphane;    respiration;    retrograde and anterograde signaling;    longevity;    cancer;   

DOI  :  10.3390/ph7090913

来源: mdpi

【 摘 要 】

Mitochondria are crucially important for maintaining not only the energy homeostasis, but the proper cellular functions in a general sense. Impairment of mitochondrial functions is observed in a broad variety of pathological states such as neoplastic transformations and cancer, neurodegenerative diseases, metabolic disorders and chronic inflammation. Currently, in parallel to the classical drug design approaches, there is an increasing interest in the screening for natural bioactive substances, mainly phytochemicals, in order to develop new therapeutic solutions for the mentioned pathologies. Dietary phytochemicals such as resveratrol, curcumin and sulforaphane are very well tolerated and can effectively complement classical pharmacological therapeutic regimens. In this paper we disscuss the effect of the chosen phytochemicals (e.g., resveratrol, curcumin, sulforaphane) on various aspects of mitochondrial biology, namely mitochondrial biogenesis, membrane potential and reactive oxygen species production, signaling to and from the nucleus and unfolded protein response.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.