Lung-Seeking Metastases

Cancers

Chandra Bortolotto¹  GiuliaM. Stella²  Silvia Benvenuti³  Stefan Kolling⁴ 

[1] Department of Intensive Medicine, Unit of Radiology, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy;Department of Medical Sciences and Infectious Diseases, Unit of Respiratory System Diseases, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy;Department of Molecular Therapeutics and Exploratory Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy;Medical School, University of Pavia, 27100 Pavia, Italy;

关键词: metastases;    lung;    metastatic niche;    biomarkers;    biomechanics;   

DOI  :  10.3390/cancers11071010

来源: DOAJ

【 摘 要 】

Metastases from different cancer types most often affect the lung parenchyma. Moreover, the lungs are among the most frequent sites of growth of metastatic masses of uncertain/unknown lineage of origin. Thus, with regards to pulmonary neoplastic parenchymal nodules, the critical issue is to determine if they are IN the lung or OF the lung. In this review, we highlight the clinical, instrumental and molecular features which characterize lung metastases, mainly focusing on recently advancing and emerging concepts regarding the metastatic niche, inflammation, angiogenesis, immune modulation and gene expression. A novel issue is related to the analysis of biomechanical forces which cooperate in the expansion of tumor masses in the lungs. We here aim to analyze the biological, genetic and pathological features of metastatic lesions to the lungs, here referred to as site of metastatic growth. This point should be a crucial part of the algorithm for a proper diagnostic and therapeutic approach in the era of personalized medicine.

【 授权许可】

Unknown