Caveolin‐1 as a promoter of tumour spreading: when, how, where and why

Journal of Cellular and Molecular Medicine

Rebecca Senetta³  Giulia Stella⁴  Ernesto Pozzi²  Niccolo Sturli¹  Daniela Massi¹ 

[1] Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy;Policlinico di Monza and Department of Molecular Medicine, University of Pavia, Monza, Italy;Department of Medical Sciences, University of Turin, Turin, Italy;Department of Molecular Medicine, Section of Pneumology, Laboratory of Biochemistry & Genetics, University and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

关键词: caveolin‐1;    cancer;    metastases;    biomarkers;    targeted therapy;   

DOI  :  10.1111/jcmm.12030

来源: Wiley

【 摘 要 】

Abstract

Caveolae are non-clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin-1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin-1 can also promote cell proliferation, survival and metastasis as well as chemo- and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin-1 in cancer development and its distant spreading. We also address the potential application of caveolin-1 in tumour therapy and diagnosis.

【 授权许可】

CC BY   
© 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.