The Use of Probiotics as Adjuvant Therapy of Periodontal Treatment: A Systematic Review and Meta-Analysis of Clinical Trials

Pharmaceutics

Carlos Enrique Cuevas-Suárez¹  Maythé Flores-Rodríguez²  Arianna Omaña-Covarrubias²  Paulo Monteiro³  Monika Lukomska-Szymanska⁴  Patrycja Proc⁵  Rim Bourgi⁶  Louis Hardan⁶  Maciej Zarow⁷  Natalia Jakubowicz⁷  Marco Nicastro⁸  Florin Lazarescu⁹ 

[1] Academic Area of Dentistry, Autonomous University of Hidalgo State, Circuito Ex Hacienda la Concepción S/N, San Agustín Tlaxiaca 42160, Hidalgo, Mexico;Academic Area of Nutrition, Autonomous University of Hidalgo State, Circuito Ex Hacienda la Concepción S/N, San Agustín Tlaxiaca 42160, Hidalgo, Mexico;Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz, CRL, Monte de Caparica, 2829-511 Caparica, Portugal;Department of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland;Department of Pediatric Dentistry, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland;Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, Lebanon;“NZOZ SPS Dentist” Dental Clinic and Postgraduate Course Centre, pl. Inwalidow 7/5, 30-033 Cracow, Poland;“Studio Nicastro” Dental Clinic, Corso Trieste 142, 00198 Roma, Italy;“Trident” Dental Clinic and Postgraduate Course Centre, Str. Dr. Louis Pasteur 1A, 050533 Bucharest, Romania;

关键词: gingivitis;    lactobacillus;    oral health;    periodontal health;    periodontal treatment outcomes;    periodontitis;   

DOI  :  10.3390/pharmaceutics14051017

来源: DOAJ

【 摘 要 】

For many years, the use of probiotics in periodontitis treatment was reflected in their abilities to control the immune response of the host to the presence of pathogenic microorganisms and to upset periodontopathogens. Accordingly, the aim of the present study was to assess the use of probiotics as adjuvant therapy on clinical periodontal parameters throughout a systematic review and meta-analysis. The literature was screened, up to 4 June 2021, by two independent reviewers (L.H. and R.B.) in four electronic databases: PubMed (MedLine), ISI Web of Science, Scielo, and Scopus. Only clinical trials that report the effect of the use of probiotics as adjuvants in the treatment of periodontal disease were included. Comparisons were carried out using Review Manager Software version 5.3.5 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). A total of 21 studies were considered for the meta-analysis. For the index plaque, the use of probiotics did not improve this clinical parameter (p = 0.16). On the other hand, for the periodontal pocket depth, the clinical attachment loss, the bleeding on probing, and the use of probiotics as adjuvant therapy resulted in an improvement of these parameters, since the control group achieved statistically higher values of this parameter (p < 0.001; p < 0.001; and p = 0.005, respectively). This study suggests that the use of probiotics led to an improvement in periodontal pocket depth, clinical attachment loss, and bleeding on probing parameters. On the other hand, this protocol seems to not be beneficial for the index plaque parameter.

【 授权许可】

Unknown