Organoids to model liver diseaseKey points

JHEP Reports

Markus H. Heim¹  Sandro Nuciforo¹ 

[1] Department of Biomedicine, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland;

关键词: Liver disease;    Disease modelling;    Organoids;    3D cultures;    Personalised medicine;    Preclinical models;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods. Liver organoids are of particular interest because of the pleiotropy of functions exerted by the human liver, their utility to model different liver diseases, and their potential application as cell-based therapies in regenerative medicine. Moreover, because they can be derived from patient tissues, organoid models offer new perspectives in personalised medicine and drug discovery. In this review, we discuss the current liver organoid models for the study of liver disease.

【 授权许可】

Unknown