Autoimmune Hypophysitis With Systemic Lupus Erythematosus: A Case Report and Literature Review

Frontiers in Endocrinology

Pengyue Xiang¹  Chaoyang Luo¹  Hua Zhang¹  Qiuxia Wu¹  Huajie Zou² 

[1] Department of Endocrinology, Jingmen No.2 People’s Hospital, Jingmen, China;Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: autoimmune hypophysitis;    systemic lupus erythematosus;    anterior pituitary hypofunction;    autoimmune disease;    sella turcica;   

DOI  :  10.3389/fendo.2020.579436

来源: DOAJ

【 摘 要 】

BackgroundAutoimmune hypophysitis (AH) is a primary autoimmune inflammatory disorder of the pituitary gland, which usually presents as a mass in the sella turcica. Systemic lupus erythematosus (SLE) is another inflammatory disorder in which the immune system attacks healthy cells and tissues throughout the body. Although both diseases are autoimmune disorders, they rarely coexist, and the relationship between them is unclear.Case ReportA 66-year-old man was evaluated at the endocrinology clinic because of worsening fatigue, anorexia, drowsiness, and leg oedema. Examination revealed alertness impairment and lower limb oedema. Laboratory tests showed anterior pituitary hypofunction. The treatment approach, with glucocorticoids and immunosuppressive agents, resulted in long-term remission of symptoms of hypopituitarism and hyponatraemia.ConclusionsOur case demonstrates a potential association between AH and SLE. AH may need to be considered in the evaluation of SLE patients with headache, hyperprolactinemia, a pituitary mass, and hypopituitarism.

【 授权许可】

Unknown