Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus

Frontiers in Immunology

Neelakshi R. Jog¹  Judith A. James² 

[1] Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States;;Departments of Medicine, Pathology, Microbiology &

关键词: Epstein-Barr virus;    systemic lupus erythematosus;    inflammation;    autoimmune disease;    viral homologs of host genes;    molecular mimicry;   

DOI  :  10.3389/fimmu.2020.623944

来源: DOAJ

【 摘 要 】

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.

【 授权许可】

Unknown