Cancer as a Metabolic Disorder

International Journal of Molecular Sciences

Jones Gyamfi¹  Junjeong Choi¹  Jinyoung Kim¹ 

[1] Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Veritas Hall D 306, 85 Songdogwahak-ro, Incheon 21983, Korea;

关键词: cancer;    metabolism;    glucose;    glutamine;    fatty acids;   

DOI  :  10.3390/ijms23031155

来源: DOAJ

【 摘 要 】

Cancer has long been considered a genetic disease characterized by a myriad of mutations that drive cancer progression. Recent accumulating evidence indicates that the dysregulated metabolism in cancer cells is more than a hallmark of cancer but may be the underlying cause of the tumor. Most of the well-characterized oncogenes or tumor suppressor genes function to sustain the altered metabolic state in cancer. Here, we review evidence supporting the altered metabolic state in cancer including key alterations in glucose, glutamine, and fatty acid metabolism. Unlike genetic alterations that do not occur in all cancer types, metabolic alterations are more common among cancer subtypes and across cancers. Recognizing cancer as a metabolic disorder could unravel key diagnostic and treatments markers that can impact approaches used in cancer management.

【 授权许可】

Unknown