Functional MRI of Letter Cancellation Task Performance in Older Adults

Frontiers in Human Neuroscience

Luke Chung¹  Simon J. Graham¹  Tom A. Schweizer³  Natasha Talwar⁴  Nathan W. Churchill⁵  Ivy D. Deng⁶  Fred Tam⁶ 

[1] Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada;Division of Neurosurgery, St. Michael’s Hospital, Toronto, ON, Canada;Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada;Institute of Medical Science, University of Toronto, Toronto, ON, Canada;Neuroscience Research Program, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada;Physical Sciences Platform, Sunnybrook Research Institute (SRI), Toronto, ON, Canada;

关键词: letter cancellation;    fMRI;    brain mapping;    neuropsychological tests;    healthy aging;   

DOI  :  10.3389/fnhum.2019.00097

来源: DOAJ

【 摘 要 】

The Letter Cancellation Task (LCT) is a widely used pen-and-paper probe of attention in clinical and research settings. Despite its popularity, the neural correlates of the task are not well understood. The present study uses functional magnetic resonance imaging (fMRI) and specialized tablet technology to identify the neural correlates of the LCT in 32 healthy older adults between 50–85 years of age, and further investigates the effect of healthy aging on performance. Subjects performed the LCT in its standard pen-and-paper administration and with the tablet during fMRI. Performance on the tablet was significantly slower than on pen-and-paper, with both response modes showing slower performance as a function of age. Across all ages, bilateral brain activation was observed in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and occipital and parietal areas. Increasing age correlated with reduced brain activity in the supplementary motor area, middle occipital gyrus, medial and inferior frontal gyrus, cerebellum and putamen. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and reduced activity in the cerebellum. The brain regions activated are associated with visuospatial attention and motor control, and are consistent with the neural correlates of LCT performance previously identified in lesion studies.

【 授权许可】

Unknown