Solid-state studies and antioxidant properties of the γ-cyclodextrin·fisetin inclusion compound

Beilstein Journal of Organic Chemistry

Filipe A. Almeida Paz¹  Joana M. Pais²  Susana S. Braga²  Maria Paula M. Marques³  Maria João Barroca³ 

[1] CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;R&D Group ‘‘Molecular Physical-Chemistry – QFM-UC”, University of Coimbra, 3004-535 Coimbra, Portugal;

关键词: antioxidant activity;    co-lyophilization;    fisetin;    gamma-cyclodextrin;    molecular encapsulation;    solid-state analysis;   

DOI  :  10.3762/bjoc.13.212

来源: DOAJ

【 摘 要 】

Fisetin is a natural antioxidant with a wide range of nutraceutical properties, including antidiabetic, neuroprotecting, and suppression or prevention of tumors. The present work describes the preparation of a water-soluble, solid inclusion compound of fisetin with gamma-cyclodextrin (γ-CD), a cyclic oligosaccharide approved for human consumption. A detailed physicochemical analysis of the product is carried out using elemental analysis, powder X-ray diffraction (PXRD), Raman, infrared and 13C{1H} CP-MAS NMR spectroscopies, and thermal analysis (TGA) to verify fisetin inclusion and to present a hypothetical structural arrangement for the host–guest units. The antioxidant activity of the γ-CD·fisetin inclusion compound is evaluated by the DPPH assay.

【 授权许可】

Unknown