Formulation and characterization of fisetin nanosuspension

International Pharmacy Conference UAD 2017 on Product Authentication: Key Factor in Quality Control of Pharmaceutical Products

Dzakwan, M.^1 ; Pramukantoro, G.E.^1 ; Mauludin, R.^2 ; Wikarsa, S.^2

Faculty of Pharmacy, Universitas Setia Budi, Central Java, Surakarta, Indonesia^1

Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia^2

关键词: Anti-solvent precipitations;    Average particle size;    Bottom up;    fisetin;    Nano-suspensions;    Polydispersity indices;    Precipitation methods;    Ultra-sonication;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/259/1/012016/pdf
DOI  :  10.1088/1757-899X/259/1/012016

来源: IOP

【 摘 要 】

Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidant that has shown to posses anticancer, antioxidant and anti-inflammatory properties. However, the poor solubility leads to poor bioavailability and limits its development. The aim of the study is to investigate the effect of fisetin nanosuspension using a precipitation-sonication method and additional stabilizers polysorbat 80, SLS, F68, PVP, PVA and HPMC on particle size average and the polydispersity index. The suspensions of microcrystalline FIS were prepared by a precipitation method with different proportion of stabilizers fixed. The nanosuspension produced was then characterized using Photon Correlation Spectroscopy (PCS) in term of particle size distribution, polydispersity index and morphology particle (SEM). Result showed fisetin nanosuspension were successfully prepared by anti-solvent precipitation with additional stabilizer SLS and PVA. The nanosuspension containing PVA showed smaller average particle size of 406 nm, a polydispersity index of 0.22±0.1 was obtained. The drug particles precipitated with the PVA as stabilizer were spherical in shape.