Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities

Molecules

Ana Jiménez-Araujo¹  Rafael Guillén-Bejarano¹  Amel Hamdi¹  Sara Jaramillo-Carmona¹  Rocío Rodríguez-Arcos¹  Mokhtar Lachaal²  Najoua Karray-Bouraoui² 

[1] Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain;Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, FST Campus, Université Tunis El Manar, 1068 Tunis, Tunisia;

关键词: Asparagus acutifolius;    phytochemicals;    antioxidant activity;    lipase inhibitory activity;    cytotoxicity;    antimicrobial activity;   

DOI  :  10.3390/molecules26113328

来源: DOAJ

【 摘 要 】

The phytochemical composition of leaves, stems, pericarps and rhizomes ethanolic extracts of Asparagus acutifolius were characterized by HPLC-DAD-MS. A. acutifolius samples contain at least eleven simple phenolics, one flavonon, two flavonols and six steroidal saponins. The stem extracts showed the highest total phenolic acid and flavonoid contents, where cafeic acid and rutin were the main compounds. No flavonoids were detected in the leaf, pericarp or rhizome while caffeic acid and ferulic acid were the predominant. Steroidal saponins were detected in the different plant parts of A. acutifolius, and the highest contents were found in the rhizome extracts. The stem extracts exhibited the highest antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) and the highest 2,2-azino-bis (3 ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity was found in the pericarp extracts. The rhizome and leaf extracts showed a potent cytotoxic activity against HCT-116 and HepG2 cell lines. Moreover, the pericarp and rhizome extracts revealed a moderate lipase inhibitory activity. The leaf and rhizome extracts were screened for their antimicrobial activity against human pathogenic isolates. The leaf extract exhibited a powerful inhibitory activity against all the bacteria and fungi tested.

【 授权许可】

Unknown