Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Molecules

Chloe D. Goldsmith³  Quan V. Vuong³  Elham Sadeqzadeh¹  Costas E. Stathopoulos²  Paul D. Roach³  Christopher J. Scarlett³ 

[1] School of Biomedical Sciences and Pharmacy, University of Newcastle, Ourimbah, NSW 2258, Australia; E-Mail:;Faculty of Bioscience Engineering, Ghent University Global Campus, Incheon 406-840, Korea; E-Mail:;Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia; E-Mails:

关键词: olive leaf;    oleuropein;    pancreatic cancer;    phenolic compounds;    Olea europaea L.;    antioxidant activity;    phytochemicals;    biophenols;   

DOI  :  10.3390/molecules200712992

来源: mdpi

【 摘 要 】

Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.