Endoscopic Screening for Second Primary Tumors of the Esophagus Among Head and Neck Cancer Patients

Frontiers in Oncology

Li-Jen Liao¹  Pei-Wei Shueng²  Deng-Yu Kuo²  Chia-Yun Wu⁴  Wu-Chia Lo⁶  Chao-Yu Liu⁷  Chen-Hsi Hsieh⁸  Chen-Shuan Chung⁹  Tzong-His Lee⁹ 

[1] Research Group, Far Eastern Memorial Hospital, New Taipei City, Taiwan;0School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan;Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan;Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan;Division of Medical Oncology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan;Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan;;Head and Neck Cancer Surveillance &Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan;

关键词: head neck cancer;    esophageal cancer;    second primary tumor;    cancer screening;    image-enhanced endoscopy;    narrow-band imaging;   

DOI  :  10.3389/fonc.2022.906125

来源: DOAJ

【 摘 要 】

Malignancies of the head and neck (HN) region and esophagus are among the most common cancers worldwide. Due to exposure to common carcinogens and the theory of field cancerization, HN cancer patients have a high risk of developing second primary tumors (SPTs). In our review of 28 studies with 51,454 HN cancer patients, the prevalence of SPTs was 12%. The HN area is the most common site of SPTs, followed by the lungs and esophagus, and 13% of HN cancer patients have been reported to have esophageal high-grade dysplasia or invasive carcinoma. The prognosis of HN cancer patients with concomitant esophageal SPTs is poor, and therefore identifying esophageal SPTs as early as possible is of paramount importance for risk stratification and to guide the treatment strategy. Image-enhanced endoscopy, especially using narrow-band imaging endoscopy and Lugol’s chromoendoscopy, has been shown to improve the diagnostic performance in detecting esophageal neoplasms at an early stage. Moreover, the early detection and minimally invasive endoscopic treatment of early esophageal neoplasm has been shown to improve the prognosis. Well-designed prospective studies are warranted to establish appropriate treatment and surveillance programs for HN cancer patients with esophageal SPTs.

【 授权许可】

Unknown