Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel

Molecules

Santiago Díaz-Oltra¹  Beatriu Escuder¹  Marco Araújo¹  Iván Muñoz Capdevila¹ 

[1] Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071 Castelló, Spain;

关键词: aldol addition;    click reaction;    tandem catalysis;    supramolecular gels;    multicomponent system;   

DOI  :  10.3390/molecules21060744

来源: DOAJ

【 摘 要 】

A heterogeneous supramolecular catalytic system for multicomponent aldol-‘click’ reactions is reported. The copper(I) metallohydrogel functionalized with a phenyltriazole fragment was able to catalyze the multicomponent reaction between phenylacetylene, p-nitrobenzaldehyde, and an azide containing a ketone moiety, obtaining the corresponding aldol products in good yields. A possible mechanistic pathway responsible for this unexpected catalytic behavior has been proposed.

【 授权许可】

Unknown