fMRI of Deep Brain Stimulation at the Rat Ventral Posteromedial Thalamus

Brain Stimulation

Bill Rogers¹  Timothy Q. Duong²  Tiwari V. Yash³  Yen-Yu Ian Shih⁴ 

[1] Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA;Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA;Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA;Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA;

关键词: Striatum;    Deep brain stimulation;    fMRI;    Thalamus;    Rat;    Isoflurane;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Functional magnetic resonance imaging (fMRI) of deep brain stimulation (DBS) has potentials to reveal neuroanatomical connectivity of a specific brain region in vivo. Objective: This study aimed to demonstrate frequency and amplitude tunings of the thalamocortical tract using DBS fMRI at the rat ventral posteromedial thalamus. Methods: Blood oxygenation level dependent (BOLD) fMRI data were acquired in a total of twelve rats at a high-field 11.7 T MRI scanner with modulation of nine stimulus frequencies (1–40 Hz) and seven stimulus amplitudes (0.2–3.6 mA). Results: BOLD response in the barrel cortex peaked at 25 Hz. The response increased with stimulus amplitude and reached a plateau at 1 mA. Cortical spreading depolarization (CSD) was observed occasionally after DBS that carries >10% BOLD waves spanning the entire ipsilateral cortex. Conclusion: fMRI is sensitive to the frequency effect of DBS and has potential to investigate the function of a particular neuroanatomical pathway.

【 授权许可】

Unknown