Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Journal of Neuroinflammation

Clement Hamani³  Antonio Carlos G. deAlmeida¹  Antonio M. Rodrigues¹  José N. Nobrega⁴  David G. de Morais²  Diego P. Nunes²  José Geraldo Brito²  Elenn Ferreira²  Luciene Covolan²  Beatriz O. Amorim² 

[1] Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei, São João del-Rei 36301-160, MG, Brazil;Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, São Paulo, 04023-062, Brazil;Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada;Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada

关键词: Caspase;    Neuroprotection;    Apoptosis;    Epilepsy;    Deep brain stimulation;    Seizures;    Thalamus;    Anterior thalamic nucleus;   

Others  :  1227065
DOI  :  10.1186/s12974-015-0384-7

 received in 2014-12-13, accepted in 2015-08-20,  发布年份 2015

【 摘 要 】

Background

Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.

Objective

The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.

Methods

Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.

Results

In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).

Conclusions

DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.

【 授权许可】

   
2015 Amorim et al.

【 图 表 】

Fig. 1.

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