Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases

Frontiers in Immunology

Jan Terje Andersen²  Torleif T. Gjølberg²  Stig Krüger³  Eirik Sundlisæter³  Panagiotis F. Christopoulos³  Guttorm Haraldsen³ 

[1] Centre for Eye Research and Department of Ophthalmology, University of Oslo and Oslo University Hospital, Oslo, Norway;Department of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway;Department of Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, Oslo, Norway;

关键词: notch;    inflammation;    autoimmunity;    gamma-secretase inhibitors (GSIs);    neutralizing antibodies;    biological therapeutics;   

DOI  :  10.3389/fimmu.2021.668207

来源: DOAJ

【 摘 要 】

The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation have proven difficult, at least partly due to the broad involvement of Notch signaling in regenerative and homeostatic processes. In this review, we summarize the supporting role of Notch signaling in various inflammation-driven diseases, and highlight efforts to intervene with this pathway by targeting Notch ligands and/or receptors with distinct therapeutic strategies, including antibody designs. We discuss this in light of lessons learned from Notch targeting in cancer treatment. Finally, we elaborate on the impact of individual Notch members in inflammation, which may lay the foundation for development of therapeutic strategies in chronic inflammatory diseases.

【 授权许可】

Unknown