Drosophila as a Model to Study the Link between Metabolism and Cancer

Journal of Developmental Biology

Stephen M. Cohen¹  Héctor Herranz¹ 

[1] Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 N Copenhagen, Denmark;

关键词: Drosophila;    animal model;    metabolism;    cancer;    Warburg effect;    obesity;    type 2 diabetes;   

DOI  :  10.3390/jdb5040015

来源: DOAJ

【 摘 要 】

Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.

【 授权许可】

Unknown