Laser induced injury caused hyperglycemia-like effect inDrosophila larva: a possible insect model for posttraumaticdiabetes

Journal of Veterinary Medical Science

Takahisa YAMADA¹  Hiroyuki KOSE²  Yoko NAKAGIRI²  Fumio OKABE² 

[1] Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Niigata 950�?2181, Japan;Department of Life Science, Division of Natural Sciences, International Christian University, Mitaka, Tokyo 181�?8585, Japan

关键词: animal model;    Drosophila;    metabolism;    posttraumatic diabetes;   

DOI  :  10.1292/jvms.14-0631

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(32)Cited-By(1)Diabetic patients need particular care in case of infection, digestive disorder orexternal injury, because external stress often exasperates the glucose metabolism, whichis known as “sick day management�?. In addition, severe trauma can be a cause ofhyperglycemia with insulin resistance. In spite of critical component of the treatment,the precise mechanisms of how trauma develops posttraumatic diabetes remain unknown. Here,we ablated body wall muscles in Drosophila larvae by laser beam and foundthat the level of trehalose, the principal sugar circulating in the hemolymph or in thetissues of most insects, was increased. The model may provide a helpful tool to understandthe relationship between trauma and sugar metabolism.

【 授权许可】

Unknown