Exosomal Sonic Hedgehog derived from cancer‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma

Cancer Medicine

Anni Zhou¹  Qingdong Guo¹  Peng Li¹  Shutian Zhang¹  Hengcun Li¹  Guiping Zhao¹  Xingyu Wang¹ 

[1] Department of Gastroenterology National Clinical Research Center for Digestive Disease Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Beijing Friendship Hospital Capital Medical University Beijing P. R. China;

关键词: cancer‐associated fibroblasts;    esophageal squamous cell carcinoma;    exosomes;    Sonic Hedgehog;   

DOI  :  10.1002/cam4.2873

来源: DOAJ

【 摘 要 】

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common and aggressive malignancies in China. Cancer‐associated fibroblasts (CAFs) can actively communicate with and stimulate tumor cells, thereby contributing to the development and progression of tumors. Yet, whether CAFs‐derived exosomes have a role in the progression of ESCC is largely unknown. Here, we find that Sonic Hedgehog (SHH) is highly expressed in CAFs lysis solution, conditioned medium of cultured CAFs (CAF‐CM) and CAFs‐derived exosomes, and esophageal cancer cell lines educated by CAF‐CM and CAFs‐derived exosomes can improve their growth and migration abilities in vitro and in vivo. Besides, those effects can be partly neutralized by cyclopamine, inhibitor of the Hedgehog signaling pathway. Thus, our research elucidates the crucial role of CAFs‐derived exosomes in the growth and progression of ESCC, and may open up new avenues in the treatment of ESCC.

【 授权许可】

Unknown