Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck

Frontiers in Medicine

article

Razvan Iacob¹  Matei Mandea¹  Speranta Iacob¹  Catalina Pietrosanu¹  Doru Paul⁵  Razvan Hainarosie¹  Cristian Gheorghe¹ 

[1] University of Medicine and Pharmacy “Carol Davila”;Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute;Center of Excellence in Translational Medicine, Fundeni Clinical Institute;Institute of Phonoaudiology and Functional ENT Surgery;Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University

关键词: liquid biopsy;    esophageal squamous cell carcinoma;    head and neck squamous cell carcinoma;    cell free DNA;    circulating tumor cells;    exosomes;   

DOI  :  10.3389/fmed.2022.827297

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications.

【 授权许可】

CC BY