Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections

Emerging Infectious Diseases

关键词: carbapenem resistance;    bloodstream infection;    Enterobacteriaceae;    carbapenem-resistant Enterobacteriaceae;    infections;    Klebsiella pneumoniae;   

DOI  :  10.3201/eid2007.121004

来源: DOAJ

【 摘 要 】

We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case–control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%–44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, −3% and −4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable.

【 授权许可】

Unknown