Glioma in Schizophrenia: Is the Risk Higher or Lower?

Frontiers in Cellular Neuroscience

Hao Xu¹  Xingchun Gao¹  Yajing Mi²  Pengtao Jiang²  Lixian Xu²  Xingchun Gou³  Ruisan Zhang³  Na Guo⁴ 

[1] Institute of Basic Medical Sciences &Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China;;Shaanxi Key Laboratory of Brain Disorders &State Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi’an, China;

关键词: schizophrenia;    glioma;    protection;    DISC1;    miRNA;   

DOI  :  10.3389/fncel.2018.00289

来源: DOAJ

【 摘 要 】

Whether persons with schizophrenia have a higher or lower incidence of cancer has been discussed for a long time. Due to the complex mechanisms and characteristics of different types of cancer, it is difficult to evaluate the exact relationship between cancers and schizophrenia without considering the type of tumor. Schizophrenia, a disabling mental illness that is now recognized as a neurodevelopmental disorder, is more correlated with brain tumors, such as glioma, than other types of tumors. Thus, we mainly focused on the relationship between schizophrenia and glioma morbidity. Glioma tumorigenesis and schizophrenia may share similar mechanisms; gene/pathway disruption would affect neurodevelopment and reduce the risk of glioma. The molecular defects of disrupted-in-schizophrenia-1 (DISC1), P53, brain-derived neurotrophic factor (BDNF) and C-X-C chemokine receptors type 4 (CXCR4) involved in schizophrenia pathogenesis might play opposite roles in glioma development. Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia. Finally, antipsychotic drugs may have antitumor effects. All these factors show that persons with schizophrenia have a decreased incidence of glioma; therefore, epidemiological investigation and studies comparing genetic and epigenetic aberrations involved in both of these complex diseases should be performed. These studies can provide more insightful knowledge about glioma and schizophrenia pathophysiology and help to determine the target/strategies for the prevention and treatment of the two diseases.

【 授权许可】

Unknown