Genetic susceptibility of COVID-19: a systematic review of current evidence

European Journal of Medical Research

Banafsheh Moradmand-Badie¹  Omid Dadras²  Mohammad Heydari³  Esmaeil Mehraeen³  Amir Masoud Afsahi⁴  Fabricio Voltarelli⁵  Mohammad Mehrtak⁶  Jean-Marc Sabatier⁷  SeyedAhmad SeyedAlinaghi⁸  Pegah Mirzapour⁸  Pedram Habibi⁸  Mehrzad MohsseniPour⁸  Alireza Barzegary⁹  Amirali Karimi^1,10 

[1] Black Dog Institute, University of New South Wales;Department of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto University;Department of Health Information Technology, Khalkhal University of Medical Sciences;Department of Radiology, School of Medicine, University of California, San Diego (UCSD);Graduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato Grosso;Healthcare Services Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences;Institut deNeuro-Physiopathologie (INP), UMR 7051, Faculté de Pharmacie, Université Aix-Marseille;Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences;School of Medicine, Islamic Azad University;School of Medicine, Tehran University of Medical Sciences;

关键词: Genetic susceptibility;    Genetic vulnerability;    Genetic probability;    COVID-19;    SARS-CoV-2;   

DOI  :  10.1186/s40001-021-00516-8

来源: DOAJ

【 摘 要 】

Abstract Introduction While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19. Methods This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020. Results According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection. Conclusion Combing through the genome, several genes related to immune system’s response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection.

【 授权许可】

Unknown