Hijacking and Use of Host Kinases by Chlamydiae

Pathogens

ErikaI. Lutter¹  Prakash Sah¹ 

[1] Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA;

关键词: Chlamydia;    kinase;    infection;    phosphorylation;    signaling;   

DOI  :  10.3390/pathogens9121034

来源: DOAJ

【 摘 要 】

Chlamydia species are causative agents of sexually transmitted infections, blinding trachoma, and animal infections with zoonotic potential. Being an obligate intracellular pathogen, Chlamydia relies on the host cell for its survival and development, subverting various host cell processes throughout the infection cycle. A key subset of host proteins utilized by Chlamydia include an assortment of host kinase signaling networks which are vital for many chlamydial processes including entry, nutrient acquisition, and suppression of host cell apoptosis. In this review, we summarize the recent advancements in our understanding of host kinase subversion by Chlamydia.

【 授权许可】

Unknown