Selective phosphorylation of human DNA methyltransferase by protein kinase C

FEBS Letters

Smith, Steven S.¹  Zucker, Keith E.¹  DePaoli-Roach, Anna²  Roach, Peter J.² 

[1] Departments of Thoracic Research and Molecular Biology, Beckman Research Institute of the City of Hope, 1450 E. Duarte Rd, Duarte, CA 91010, USA;Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46223, USA

关键词: DNA methylation (Human placenta) DNA methyltransferase Phorbol ester Protein kinase C Protein phosphorylation;   

DOI  :  10.1016/0014-5793(86)80316-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.

【 授权许可】

Unknown