White matter and its relationship with cognition in subjective cognitive decline

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Jodie R. Gawryluk¹  Lisa Ohlhauser¹  Alzheimer's Disease Neuroimaging Initiative¹  Ashleigh F. Parker¹  Colette M. Smart¹ 

[1] Department of PsychologyUniversity of VictoriaVictoriaBritish ColumbiaCanada;

关键词: Subjective cognitive decline;    Diffusion tensor imaging;    Executive function;    Memory;    Alzheimer's disease;   

DOI  :  10.1016/j.dadm.2018.10.008

来源: DOAJ

【 摘 要 】

Abstract Introduction Subjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memory and executive function. Methods Diffusion tensor imaging and neuropsychological assessment data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 30 individuals with SCD and 44 control subjects. Results Results revealed significantly lower white matter integrity in individuals with SCD relative to control subjects in widespread regions, including the bilateral corticospinal tracts, superior and inferior longitudinal fasciculi, fronto‐occipital fasciculi, corpus callosum, forceps major and minor, hippocampi, anterior thalamic radiations, and the cerebellum. There was a widespread relationship between diffusion tensor imaging metrics and executive function in SCD, but not healthy control subjects, and no relationship with memory for either group. Discussion Relatively lower white matter integrity in SCD may be a useful early biomarker for risk of future cognitive decline. Future research should better characterize the SCD group longitudinally and in individuals at risk for Alzheimer's disease.

【 授权许可】

Unknown