Modes of Brain Cell Death Following Intracerebral Hemorrhage

Frontiers in Cellular Neuroscience

Guofeng Wu²  Zhouping Tang³  Ruiyi Zhang⁴  Yan Zhang⁴  Hongmin Li⁴  Suliman Khan⁴  Yang Liu⁴  Mengzhou Xue⁴  V. Wee Yong⁵ 

[1] Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, China;Department of Neurology, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China;Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada;

关键词: intracerebral hemorrhage;    cell death;    apoptosis;    necrosis;    ferroptosis;    autophagy;   

DOI  :  10.3389/fncel.2022.799753

来源: DOAJ

【 摘 要 】

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.

【 授权许可】

Unknown