Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset

Cancers

Alessandro Fichera¹  Jun Gong²  Karen Zaghiyan²  Eiman Firoozmand²  Maryliza S. El-Masry²  Jane C. Figueiredo²  Andrew Hendifar²  Alexandra Gangi²  Robert W. Decker²  David M. Hoffman²  Kyle G. Cologne²  Beth A. Moore²  Zuri A. Murrell²  Yosef F. Nasseri²  Justin Monroe³  David Shibata³  Nathan Hinkle³  Deyali Chatterjee⁴  Matthew Mutch⁴  Cory Bernadt⁴  Adetunji T. Toriola⁴  Ravi Moonka⁵  Christopher I. Li⁵  Ulrike Wallin⁵  Mukta Krane⁵  Mika Sinanan⁵  Deepti Reddi⁵  Paul D. Lampe⁵  William M. Grady⁵  Stacey A. Cohen⁵  Seth Felder⁶  Sophie Dessureault⁶  Erin M. Siegel⁶  Stephanie L. Schmit⁶  Domenico Coppola⁶  Julian Sanchez⁶  Cornelia M. Ulrich⁷  Jolanta Jedrzkiewicz⁷  Jennifer Ose⁷  Mary Bronner⁷  Bartley Pickron⁷  Lyen C. Huang⁷  Caroline Himbert⁷  Sheetal Hardikar⁷  Anita R. Peoples⁷  Courtney L. Scaife⁷  Eric Swanson⁷  Tengda Lin⁷  Laura Lambert⁷  Jessica N. Cohan⁷  Magnus von Knebel-Doeberitz⁸  Alexis B. Ulrich⁸  Esther Herpel⁸  Johanna Nattenmueller⁸  Matthias Kloor⁸  Biljana Gigic⁸  Peter Schirmacher⁸  Hans-Ulrich Kauczor⁸ 

[1] Baylor Scott & White Health, Dallas, TX 76712, USA;Cedars-Sinai Center, Los Angeles, CA 90048, USA;Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA;Department of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA;Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA;Huntsman Cancer Institute, Salt Lake City, UT 84112, USA;Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany;

关键词: early onset;    colorectal cancer;    cohort;    epidemiology;   

DOI  :  10.3390/cancers13153817

来源: DOAJ

【 摘 要 】

Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m², 52% colon cancers, 21% early-onset, and presented with stage II or III (60%) disease. Early-onset patients presented with more advanced disease (stages III–IV: 63% vs. 51%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95% confidence interval (CI)) = 2.30 (1.82–3.83) and 2.00 (1.43–2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21–1.98) and 0.56 (0.41–0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight.

【 授权许可】

Unknown