Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications

Nanomaterials

Kyung-Sun Kang¹  Insung Kang¹  Donghoon Kim²  Je Min Min Yoo³  Mina Park³  Juhee Kim³  Joonhee Moon⁴  Yeonjoon Suh⁵  Byung Hee Hee Hong⁵  Dong Jin Jin Kim⁶ 

[1] Adult Stem Cell Research Center and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea;BIOGRAPHENE, Los Angeles, CA 90013, USA;Department of Chemistry, Seoul National University, Seoul 08826, Korea;Division of Analytical Science Research, Korea Basic Science Institute (KBSI) Daejeon 34133, Korea;Graphene Research Center, Advanced Institute of Convergence Technology, Suwon 16229, Korea;Program in Nano Science and Technology, Graduate school of Convergence Science and Technology, Seoul National University, Seoul 08826, Korea;

关键词: graphene;    graphene quantum dots;    nanomedicine;    Parkinson’s disease;   

DOI  :  10.3390/nano11061423

来源: DOAJ

【 摘 要 】

Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficacy of GQDs was reported against Parkinson’s disease, which has to date remained incurable. Herein, we present an environmentally friendly approach for synthesizing GQDs through a waste-to-treasure method, specifically from coffee waste to nanodrug. Consistent with the previous findings with carbon fiber-derived GQDs, the inhibitory effects of coffee bean-derived GQDs demonstrated similar effectiveness against abnormal α-synuclein fibrillation and the protection of neurons from relevant subcellular damages. The fact that a GQDs-based nanodrug can be prepared from a non-reusable yet edible source illustrates a potential approach to convert such waste materials into novel therapeutic agents with minimal psychological rejection by patients.

【 授权许可】

Unknown