Graphene Quantum Dots’ Surface Chemistry Modulates the Sensitivity of Glioblastoma Cells to Chemotherapeutics

International Journal of Molecular Sciences

Gabriele Ciasca¹  Giordano Perini¹  Marco De Spirito¹  Massimiliano Papi¹  Valentina Palmieri¹  Marcello D’Ascenzo¹  Jacopo Gervasoni²  Wanda Lattanzi²  Chiara Prampolini²  Ornella Parolini²  Federica Tiberio²  Aniello Primiano²  Daniela Fioretti³  Monica Rinaldi³ 

[1] Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy;Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy;Institute of Translational Pharmacology (ITF), Department of Biomedical Sciences, National Research Council (CNR), 00168 Rome, Italy;

关键词: nanomedicine;    graphene quantum dots;    glioblastoma;    cancer treatment;    synergistic therapy;   

DOI  :  10.3390/ijms21176301

来源: DOAJ

【 摘 要 】

Recent evidence has shown that graphene quantum dots (GQDs) are capable of crossing the blood–brain barrier, the barrier that reduces cancer therapy efficacy. Here, we tested three alternative GQDs’ surface chemistries on two neural lineages (glioblastoma cells and mouse cortical neurons). We showed that surface chemistry modulates GQDs’ biocompatibility. When used in combination with the chemotherapeutic drug doxorubicin, GDQs exerted a synergistic effect on tumor cells, but not on neurons. This appears to be mediated by the modification of membrane permeability induced by the surface of GQDs. Our findings highlight that GQDs can be adopted as a suitable delivery and therapeutic strategy for the treatment of glioblastoma, by both directly destabilizing the cell membrane and indirectly increasing the efficacy of chemotherapeutic drugs.

【 授权许可】

Unknown