Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

Indonesian Journal of Chemistry

Mohd Ridzuan Mohd Abdul Razak¹  Rozie Sarip²  Nur Adila Fatin Mohd Khir²  Nur Rahimah Fitrah Mohd Sofyan²  Nur Fadilah Rajab³  Fariza Juliana Nordin³ 

[1]Bioassay Unit, Herbal Medicine Research Centre (HMRC), Institute for Medical Research (IMR), Jl. Pahang, 50588 Kuala Lumpur, Malaysia

[2]Department of Chemistry, Faculty of Science, University of Malaya (UM), Lembah Pantai, 50603 Kuala Lumpur, Malaysia

[3]Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur Campus, Jl. Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

关键词: thiosemicarbazone;    silver complexes;    antiplasmodial;    antiproliferative;    phosphine;   

DOI  :  10.22146/ijc.57343

来源: DOAJ

【 摘 要 】

A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as 1H, 13C, 31P{1H}s, COSY, and 1H-13C nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.

【 授权许可】

Unknown