Preparation of Polyester-Based Metal-Cross Linked Polymeric Composites as Novel Materials Resistant to Bacterial Adhesion and Biofilm Formation

Molecules

Suhair Saleh¹  Bassam Sweileh¹  Sami O. Taha¹  Ruhaifa Mahmoud¹ 

[1] ¹Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan

关键词: bacterial biofilms;    2;    6-pyridinedicarboxylate;    copper complexes;    silver complexes;    polyesters;   

DOI  :  10.3390/molecules16010933

来源: mdpi

【 摘 要 】

Bacterial biofilms constitute an extremely resistant form of bacterial colonization with dire health and economical implications. Towards achieving polymeric composites capable of resisting bacterial adhesion and biofilm formation, we prepared five 2,6-pyridinedicarboxylate-based polyesters employing five different diol monomers. The resulting polyesters were complexed with copper (II) or silver (I). The new polymers were characterized by proton and carbon nuclear magnetic resonance spectroscopy, inherent viscosity, infrared spectroscopy, differential scanning calorimetry and thermogravimetric analysis. The corresponding metal complexes were characterized by differential scanning calorimery and infrared spectroscopy. The amounts of complexed copper and silver were determined by atomic absorption spectrophotometry. Finally, the resulting composites were tested for their antibacterial potential and were found to effectively resist bacterial attachment and growth.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.