Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Bioactive Materials

Guojiang Wan¹  Haijun Zhang²  Chao Zhou³  Dorothea Alexander⁴  Xiaoshan Mo⁵  Wentai Zhang⁵  Gang Shen⁵  Jürgen Geis-Gerstorfer⁶  Ping Li⁶  Frank Rupp⁶ 

[1] Corresponding author. Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstr. 2-8, Tübingen, 72076, Germany.;Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstrasse 2-8, Tübingen, 72076, Germany;Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China;Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Osianderstrasse 2-8, Tübingen, 72076, Germany;Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China;Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstrasse 2-8, Tübingen, 72076, Germany;

关键词: Zn-based biodegradable metal;    Mechanical properties;    Degradation behavior;    Biocompatibility;    Guided bone regeneration membrane;   

DOI  :  

来源: DOAJ

【 摘 要 】

Appropriately adapted comprehensive mechanical properties, degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants. In this study, hot-extruded Zn–0.5Cu–xFe (x = 0.1, 0.2 and 0.4 wt%) alloys were fabricated as candidates for biodegradable materials for guided bone regeneration (GBR) membranes. The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties, and the Fe alloying was added mainly for regulating the degradation. The microstructure, mechanical properties and in vitro degradation behavior were systematically investigated. The ZnCuFe alloys were composed of a Zn matrix and FeZn13 phase. With increasing Fe content, a higher FeZn13 phase precipitation with larger particles was observed. Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%, the ZnCuFe (0.2 wt%) alloy achieved a good balance between mechanical strength and ductility, with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%. Moreover, the addition of Fe successfully accelerated the degradation of ZnCuFe alloys. The ZnCuFe (0.2 wt%) alloy showed relatively uniform corrosion in the long-term degradation test. Furthermore, extracts of the ZnCuFe (0.2 wt%) alloy showed no apparent cytotoxic effects against L929 fibroblasts, Saos-2 osteoblasts or TAg periosteal cells. The ZnCuFe (0.2 wt%) alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria. Our study provides evidence that the ZnCuFe (0.2 wt%) alloy can represent a promising material for the application as a suitable GBR membrane.

【 授权许可】

Unknown