In vitro and in vivo studies on pure Mg, Mg–1Ca and Mg–2Sr alloys processed by equal channel angular pressing

Nano Materials Science

Olga B. Kulyasova¹  Kelvin W.K. Yeung²  Yunong Shen³  Xiao Liu⁴  Danni Shen⁴  Wenting Li⁴  Yufeng Zheng⁴  Shaokang Guan⁵  Jie Shen⁵  R.Z. Valiev⁶ 

[1] Corresponding author.;Corresponding author;College of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China;Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China;Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China;School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China;

关键词: Magnesium alloys;    Equal channel angular pressing;    Mechanical property;    Degradation behavior;    Biocompatibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

In the present work, the biomedical as-cast pure Mg, Mg–1Ca and Mg–2Sr alloys were processed with equal channel angular pressing (ECAP) technique to develop ultrafine microstructure within the materials, and their microstructures, mechanical properties, degradation behavior, cytocompatibility in vitro and biocompatibility in vivo were studied comprehensively. Finer-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast counterparts. Moreover, after ECAP the degradation rate of pure Mg was increased while that of Mg–1Ca or Mg–2Sr alloys decreased compared to the as-cast counterparts. Additionally, good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3T3-E1 and human mesenchymal stem cells (hMSC) and in vivo animal tests at the lateral epicondyle of SD-rats’ femur. This study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals. It might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.

【 授权许可】

Unknown