Applied Sciences | |
Synthesis and Surface Modification of Nanostructured F-Doped ZnO: Toward a Transducer for Label-Free Optical Biosensing | |
Giuseppe Vitiello1  Antonio Aronne1  Giovanna Chianese2  Rosalba Moretta2  Monica Terracciano2  Ilaria Rea2  Luca De Stefano2  Chiara Schiattarella2  Paolo Cappiello2  | |
[1] Department of Chemical, Materials and Production Engineering, Federico II University of Naples, 80138 Naples, Italy;National Research Council, Institute for Microelectronics and Microsystems, Unit of Naples, 80131 Naples, Italy; | |
关键词: nanostructured zinc oxide; hydrothermal synthesis; bioconjugation; photoluminescence; | |
DOI : 10.3390/app9163380 | |
来源: DOAJ |
【 摘 要 】
In this work, the surface of nanostructured fluorine-doped ZnO (nZnO·F) is functionalized with protein A (PrA), and used as a model biomolecule. The chemical procedure is characterized by several analytical techniques such as Fourier Transform Infrared Spectroscopy, water contact angle analysis, and fluorescence microscopy. The surface modification of nZnO·F by binding increasing concentrations of PrA is also investigated by two label-free optical techniques, i.e., the spectroscopic reflectometry and the steady-state photoluminescence. The results are compared with those obtained using undoped nZnO substrates in order to highlight the better performances of nZnO·F due to the fluorine doping. The results of this study pave the way for the design and realization of a ZnO-based nanostructured platform for label-free optical sensing.
【 授权许可】
Unknown