Novel Insights Into the Role of Mitochondria-Derived Peptides in Myocardial Infarction

Frontiers in Physiology

Geng Qian¹  Dan Wu¹  Enny Kampmann² 

[1] Department of Cardiology, The First Medical Center, Chinese People’s Liberation Army Hospital, Medical School of Chinese People’s Liberation Army, Beijing, China;School of Life Sciences, City College of San Francisco, San Francisco, CA, United States;

关键词: myocardial infarction;    mitochondria-derived peptides;    mitochondria;    mitochondria-ER communication;    heart;   

DOI  :  10.3389/fphys.2021.750177

来源: DOAJ

【 摘 要 】

Mitochondria-derived peptides (MDPs) are a new class of bioactive peptides encoded by small open reading frames (sORFs) within known mitochondrial DNA (mtDNA) genes. MDPs may affect the expression of nuclear genes and play cytoprotective roles against chronic and age-related diseases by maintaining mitochondrial function and cell viability in the face of metabolic stress and cytotoxic insults. In this review, we summarize clinical and experimental findings indicating that MDPs act as local and systemic regulators of glucose homeostasis, immune and inflammatory responses, mitochondrial function, and adaptive stress responses, and focus on evidence supporting the protective effects of MDPs against myocardial infarction. These insights into MDPs actions suggest their potential in the treatment of cardiovascular diseases and should encourage further research in this field.

【 授权许可】

Unknown