Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System

Frontiers in Physiology

Corina Bello¹  Markus M. Luedi¹  Maks Mihalj³  Thierry Carrel⁴  Paul Philipp Heinisch⁵ 

[1] Department of Anaesthesiology and Pain Medicine, Bern University Hospital (Inselspital), University of Bern, Bern, Switzerland;Department of Anaesthesiology, Spital Grabs, Grabs, Switzerland;Department of Cardiovascular Surgery, Bern University Hospital (Inselspital), Bern, Switzerland;Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland;Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technical University, Munich, Germany;

关键词: immune system;    cardiac surgery;    indoleamine-2;    3-dioxygenase;    tryptophan;    immunosuppression;   

DOI  :  10.3389/fphys.2021.766511

来源: DOAJ

【 摘 要 】

Indoleamine-2,3-dioxygenase (IDO) is the “rate-limiting” enzyme in the kynurenine (Kyn) pathway of the tryptophan (Trp) catabolism. By its immune-modulatory effect, IDO initiates changes to the physiologically balanced immune state and plays a key role in the pathogenesis of various diseases, as well as in the perioperative setting during surgery. In autoimmune processes, highly malignant cancers such as glioblastoma or organ transplantation, IDO’s involvement has been studied extensively. However, in severe systemic infections, as present in sepsis, it is not yet completely understood. Hereafter, in this narrative review, we present the current knowledge of IDO’s implication on such complex immune-related processes. Moreover, we address the role of IDO as a predictive biomarker as well as a therapeutic target for immune-mediated diseases. Finally, we discuss IDO in the setting of surgical trauma-induced stress and highlight its promising use as a biomarker in the pre-operative setting for all disciplines involved in the decision-making process and treatment of patients undergoing surgery.

【 授权许可】

Unknown