Contribution of IDO to human respiratory syncytial virus infection

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Felipe M. Benavente¹  Jorge A. Soto¹  Magdalena S. Pizarro-Ortega¹  Karen Bohmwald¹  Pablo A. González¹  Susan M. Bueno¹  Alexis M. Kalergis¹ 

[1] Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile

关键词: indoleamine-2;    3-dioxygenase;    tryptophan (Trp);    hRSV;    T cells;   

DOI  :  10.1002/JLB.4RU0219-051RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

IDO is an enzyme that participates in the degradation of tryptophan (Trp), which is an essential amino acid necessary for vital cellular processes. The degradation of Trp and the metabolites generated by the enzymatic activity of IDO can have immunomodulating effects, notably over T cells, which are particularly sensitive to the absence of Trp and leads to the inhibition of T cell activation, cell death, and the suppression of T cell effector functions. Noteworthy, T cells participate in the cellular immune response against the human respiratory syncytial virus (hRSV) and are essential for viral clearance, as well as the total recovery of the host. Furthermore, inadequate or non-optimal polarization of T cells is often seen during the acute phase of the disease caused by this pathogen. Here, we discuss the capacity of hRSV to exploit the immunosuppressive features of IDO to reduce T cell function, thus acquiring relevant aspects during the biology of the virus. Additionally, we review studies on the influence of IDO over T cell activation and its relationship with hRSV infection.

【 授权许可】

CC BY