Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study

BMC Gastroenterology

Umer Z. Ijaz¹  Tracey Cardigan²  Elaine Buchanan²  Rachel Tayler²  Andrew R. Barclay²  Vikki Garrick²  Lee Curtis²  Richard Hansen²  Diana M. Flynn²  Lisa Gervais²  Lawrence Armstrong³  Hazel Duncan³  Caroline Delahunty⁴  Vaios Svolos⁵  Michael Logan⁵  Konstantinos Gerasimidis⁵  Ben Nichols⁵  Konstantinos Gkikas⁵  Clare M. Clark⁵  Simon Milling⁶  Richard K. Russell⁷ 

[1] Civil Engineering, School of Engineering, University of Glasgow;Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children;Department of Paediatrics, Crosshouse Hospital;Department of Paediatrics, Wishaw General Hospital;Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow;Institute for Infection, Immunity and Inflammation, University of Glasgow;Royal Hospital for Children and Young People;

关键词: Crohn’s disease;    Food reintroduction;    Dietary triggers;    Faecal calprotectin;    Gluten;    Fibre;   

DOI  :  10.1186/s12876-021-02029-4

来源: DOAJ

【 摘 要 】

Abstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut of children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed disease dietary triggers following successful treatment with exclusive enteral nutrition. Methods Nutrient intake, dietary patterns and dietary biomarkers in faeces (gluten immunogenic peptides, undigestible starch, short chain fatty acids) were assessed in 14 children with Crohn’s disease during early food reintroduction, following exclusive enteral nutrition. Groups above (Group A) and below (Group B) the median levels of faecal calprotectin after food reintroduction were assigned for comparative analysis. Results Intakes of fibre, gluten-containing cereals and red and processed meat were significantly higher in Group A than Group B; (median [Q1, Q3], g/day; Fibre: 12.1 [11.2, 19.9] vs. 9.9 [7.6, 12.1], p = 0.03; Red and processed meat: 151 [66.7, 190] vs. 63.3 [21.7, 67], p = 0.02; gluten-containing cereals: 289 [207, 402] vs. 203 [61, 232], p = 0.035). A diet consisting of cereals and meat products was predictive (92% accuracy) of higher faecal calprotectin levels after food reintroduction. In faeces, butyrate levels, expressed as absolute concentration and relative abundance, were higher in Group A than Group B by 28.4 µmol/g (p = 0.015) and 6.4% (p = 0.008), respectively. Levels of gluten immunogenic peptide and starch in faeces did not differ between the two groups. Conclusions This pilot study identified potential dietary triggers of gut inflammation in children with Crohn’s disease after food reintroduction following treatment with exclusive enteral nutrition. Trial registration: Clinical trials.gov registration number: NCT02341248; Clinical trials.gov URL: https://clinicaltrials.gov/ct2/show/NCT02341248 (retrospectively registered).

【 授权许可】

Unknown