Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Nutrients

MaríaDolores Chirlaque López¹  Maria-Jose Sánchez¹  Antonio Agudo²  JulieA. Schmidt³  Rosario Tumino⁴  Giovanna Masala⁵  AliciaK. Heath⁶  David Muller⁶  Joanna Clasen⁶  Therese Karlsson⁷  Paolo Chiodini⁸  MatthiasB. Schulze⁹  Heleen Van Puyvelde^1,10  Dirk De Bacquer^1,10  Koen Van Herck^1,10  Lode Godderis^1,11  Kim Overvad^1,12  Jonas Manjer^1,13  Ulrika Ericson^1,14  Anne Tjønneland^1,15  Jytte Halkjær^1,15  Verena Katzke^1,16  RenéeT. Fortner^1,16  Valeria Pala^1,17  MarijeF. Bakker^1,18  Eva Ardanaz^1,19  Geneviève Nicolas^2,20  Pietro Ferrari^2,20  Inge Huybrechts^2,20  Carine Biessy^2,20  Nikos Papadimitriou^2,20  Corinne Casagrande^2,20  MarcJ. Gunter^2,20  Elisabete Weiderpass^2,21  Björn Gylling^2,22  Carlotta Sacerdote^2,23 

[1]CIBER Epidemiology and Public Health CIBERESP, 28029 Madrid, Spain

[2]Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Institut Català d’Oncologa, 08908 L’Hospitalet de Llobregat, Barcelona, Spain

[3]Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 LF7, UK

[4]Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, Italy

[5]Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, 50139 Firenze, Italy

[6]Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Hospital, London W2 1PG, UK

[7]Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden

[8]Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

[9]Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany

[10]Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

[11]Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium

[12]Department of Public Health, Aarhus University, DK-8000 Aarhus C, Denmark

[13]Department of Surgery, Skåne University Hospital Malmö, Lund University, Bröstmottagningen, 214 28 Malmö, Sweden

[14]Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, 205 02 Malmö, Sweden

[15]Diet, Genes and Environment, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark

[16]Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany

[17]Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, 1, 20133 Milano, Italy

[18]Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands

[19]Navarra Public Health Institute, 31003 Pamplona, Spain

[20]Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France

[21]Office of the Director, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France

[22]Unit Pathology, Department of Medical Biosciences, Umeå Universitet, 901 85 Umeå, Sweden

[23]Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, 10126 Turin, Italy

关键词: breast cancer;    folate;    choline;    betaine;    methionine;    EPIC;   

DOI  :  10.3390/nu13061843

来源: DOAJ

【 摘 要 】

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.

【 授权许可】

Unknown