The Footprint of Diabetes Mellitus on the Characteristics and Response to Anti-Tuberculous Therapy in Patients with Pulmonary Tuberculosis from Saudi Arabia

Infection and Drug Resistance

关键词: pulmonary;    tuberculosis;    diabetes;    comorbidity;    impact;   

DOI  :  

来源: DOAJ

【 摘 要 】

Rania Abd El-Hamid El-Kady,1,2 Safaa Abdulrahman Turkistani3 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Department of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia; 3Department of Medical Laboratory Sciences, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi ArabiaCorrespondence: Rania Abd El-Hamid El-KadyDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, PO Box 2537, Jeddah, Kingdom of Saudi ArabiaTel [phone]Email [e-mail]: Right now, a tuberculosis (TB) and diabetes mellitus (DM) syndemic is re-emerging worldwide. Given the contradictory results of the impact of DM on the natural history of pulmonary TB (PTB), this study was undertaken to shed light on the precision of this hypothesis from a community with a substantial caseload of both diseases.Methods: The present 5-year, retrospective, cohort study involved 487 (60.8% males, and 39.2% females) adult PTB patients (mean age 53.71 ± 15.78 years) selected from Dr. Soliman Fakeeh Hospital (DSFH), Jeddah, Kingdom of Saudi Arabia (KSA). The relevant patients’ clinical, radiological and microbiological data were extracted from the hospital medical and laboratory database.Results: In our study, the cumulative prevalence of DM among PTB subjects was 27.1%. Both diabetic and non-diabetic groups were matched with regard to gender (p = 0.46); however, diabetic patients were significantly older (p = 0.0001). Patients with concomitant DM displayed higher frequency of the classic clinical presentations of PTB and were 1.8 times more likely to have cavitary lesions on imaging studies (p = 0.012). Furthermore, diabetic patients showed higher initial sputum acid-fast bacillus (AFB) smear grade (p = 0.0001) and were more prone to have delayed culture conversion as compared to their non-diabetic counterparts (77.55 ± 37.74 versus 54.95 ± 27.67 days, respectively; p = 0.0001) which points out to less favorable treatment outcome.Conclusion: DM showed an impact on different aspects of PTB. Accordingly, integrated bi-directional screening programs for both diseases in the KSA need to be implemented to upgrade health-care services of patients with dual diagnosis.Keywords: pulmonary, tuberculosis, diabetes, comorbidity, impact

【 授权许可】

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