Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin

Vaccines

Sabari Nath Neerukonda¹  Carol D. Weiss¹  Russell Vassell¹ 

[1] Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA;

关键词: influenza;    hemagglutinin;    broadly neutralizing antibodies;    universal influenza vaccines;   

DOI  :  10.3390/vaccines8030382

来源: DOAJ

【 摘 要 】

Influenza continues to be a public health threat despite the availability of annual vaccines. While vaccines are generally effective at inducing strain-specific immunity, they are sub-optimal or ineffective when drifted or novel pandemic strains arise due to sequence changes in the major surface glycoprotein hemagglutinin (HA). The discovery of a large number of antibodies targeting the highly conserved stem region of HAs that are capable of potently neutralizing a broad range of virus strains and subtypes suggests new ways to protect against influenza. The structural characterization of HA stem epitopes and broadly neutralizing antibody paratopes has enabled the design of novel proteins, mini-proteins, and peptides targeting the HA stem, thus providing a foundation for the design of new vaccines. In this narrative, we comprehensively review the current knowledge about stem-directed broadly neutralizing antibodies and the structural features contributing to virus neutralization.

【 授权许可】

Unknown