Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures

Molecules

Iride Mascheretti¹  Roméo A. Dougué Kentsop¹  Franca Locatelli¹  Monica Mattana¹  Michela Alfieri²  Gianluca Ottolina²  Roberto Consonni² 

[1] Institute of Agricultural Biology and Biotechnology, National Research Council, Via Bassini 15, 20133 Milan, Italy;Institute of Chemical Sciences and Technologies “Giulio Natta”, National Research Council, Via Mario Bianco 9, 20131 Milan, Italy;

关键词: Linum;    aryltetralin lignans;    6-methoxypodophyllotoxin;    elicitor;    NMR;    methyl jasmonate;   

DOI  :  10.3390/molecules26175189

来源: DOAJ

【 摘 要 】

Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human health, in particular, for their potent antiviral and antineoplastic properties. In this study, the adventitious root cultures of three Linum species (L. flavum, L. mucronatum and L. dolomiticum) were developed to produce aryltetralin lignans. The effect of two elicitors, methyl jasmonate and coronatine, on aryltetralin lignans production was also evaluated. The adventitious root cultures from L. dolomiticum were obtained and analyzed for the first time and resulted as the best producer for all the aryltetralins highlighted in this system: Podophyllotoxin, 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside, the last showing a productivity of 92.6 mg/g DW. The two elicitors differently affected the production of the 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside.

【 授权许可】

Unknown